What is FirstLook Lung?

FirstLook Lung is a noninvasive, blood-based test that uses AI and fragmentomics to identify individuals at higher risk for lung cancer before or alongside low-dose CT screening. It's designed for adults eligible for lung cancer screening under USPSTF guidelines and gives providers a convenient, accessible, and reliable approach to enhance lung cancer screening. With a simple blood test, FirstLook helps determine the likelihood of detecting lung cancer through low-dose CT (LDCT).

Who is eligible for FirstLook Lung?

FirstLook Lung is for adults aged 50-80 with 20+ pack-year smoking history who currently smoke or quit within the past 15 years.

How does FirstLook Lung work?

FirstLook Lung uses next-generation sequencing to analyze genome-wide DNA fragmentation patterns in blood, an approach called fragmentomics. Cancer cells release DNA differently than healthy cells, creating distinct patterns that the test detects to indicate the likelihood of lung cancer presence.

What are the benefits for health systems?

FirstLook Lung improves patient engagement with lung cancer screening and integrates seamlessly into existing EHR workflows.

What is the test performance?

FirstLook Lung has 99.8% negative predictive value (NPV) and is clinically validated for lung cancer screening in USPSTF-eligible individuals.

Which health systems use FirstLook Lung?

FirstLook Lung clinical collaboration partners include: Allegheny Health Network, City of Hope, OSF Healthcare.

A Breakthrough in Early Detection

 

Discover how DELFI's innovative blood test leverages cutting-edge genomic technology to help detect lung cancer at earliest stages.

DELFI's FirstLook Lung test identifies genome-wide alterations associated with lung cancer at high sensitivity using a simple blood draw.1,2

Intended for individuals deemed eligible for lung cancer screening by the United States Preventative Services Task Force (USPSTF), FirstLook Lung helps determine the likelihood of detecting lung cancer through Low-Dose Computed Tomography (LDCT).

FirstLook Lung is designed to be a convenient first step in detecting lung cancer early, when it is most treatable.

Building Evidence Through Strategic Health System Collaborations

Leading academic medical centers and integrated delivery networks have partnered with DELFI to implement the FirstLook Lung cancer screening solution and, in some instances, contribute to clinical evidence for early detection programs.

These strategically selected health systems - including several of the nation's most respected healthcare institutions - collaborate with our team to optimize lung cancer screening workflows, improve patient outcomes, and demonstrate their commitment to innovative preventive care.

Their experience showcases how adopting cutting-edge technology can transform cancer screening programs while delivering measurable clinical and operational value.

Our health system partners and collaborators include
(alphabetical order):

CANCER DISCOVERY

 

Read Manuscript

Read the original validation study1 of the FirstLook Lung test published in Cancer Discovery.

The Advantages of FirstLook Lung Screening

  • 99.8% negative predictive value and clinically validated for lung cancer2

  • Earlier detection enables earlier intervention

  • Treating cancer sooner focuses resources on ensuring better outcomes

  • Improved patient engagement in early lung cancer detection

  • Seamless integration into existing healthcare systems with best-practice alerts and advanced EHR integration capabilities

  • A simple lab test-ordering process; no extensive training or additional equipment is needed

  • Patient and provider-focused educational materials to support outreach teams

Important Insights: Just a Click Away

 

Gain a deeper understanding of our fragmentomics technology by downloading and reading our brochure. This document provides an overview of DELFI and how we utilized our technology to create the FirstLook Lung cancer screening test.

 

Download

Ready to Enhance Lung Cancer Screening in Your Network?

Schedule a meeting with our partnership executives to discuss how our innovative genomics solution with FirstLook can become part of your lung cancer screening program. Learn about the applications of fragmentomics research and non-invasive cancer testing.

Let us help you take the next steps in improving your organization's patient care and resource allocation through next-generation blood-based tests and cfDNA testing.

 

Schedule a Meeting

References: 1. Mazzone, P.J., Bach, P.B., Carey, J., et al. Cancer Discovery. 10.1158 – 2159-8290. CD-24-0519. (2024).  2. Unpublished data on file.

FirstLook Lung is intended to be an adjunct, qualitative aid evaluating adults eligible for LDCT lung cancer screening. It is designed to supplement, not supplant, recommended screening tests for lung cancer in the population described in the Indications for Use, including LDCT examination.

The FirstLook Lung test is a laboratory-developed test. It was developed and its performance characteristics determined by DELFI Diagnostics. It has not been cleared or approved by the FDA. The laboratory is regulated under the Clinical Laboratory Improvement Act (CLIA) as qualified to perform high complexity clinical tests. This test is used for clinical purposes. It should not be regarded as investigational or for research.

FirstLook is a trademark of DELFI Diagnostics, Inc. used worldwide.